forHisglory's advice is spot on. I'm almost 47 and going to community college, finishing up my first year. I plan on transferring to get my BA after graduation.
Some things I find helpful:
Speak up and don't be afraid to ask questions in class.
Periodically re-review your syllabi. You'll have papers and projects due at certain times and this will help you plan ahead for them. Consider keeping a planner, either on-line or one you carry with you.
I know it goes without saying, but show up for all your classes. Don't miss any unless you can't avoid it. My profs like to give micro-quizzes worth a few points during class, and they add up. A lot of times they like to give them on days when a lot of students are absent, as a reward to those who are present. There may be times when they are enough to bump your grade up to the next higher grade. Also, you may miss out on important info if you miss the lecture.
Sign up for tutoring. And sign up for lab classes for the classes you know you will need extra help in, like math or english.
Try not to take math and english in the same semester, if you can help it. They both tend to be homework-intensive. And I am taking both math and english this semester and it's kind of kicking my butt, but I'm getting A's so far. But I put a LOT of study/homework hours in a week. So keep that in mind.
We are not 20-something anymore. You will get fatigued. Take care of yourself, and rest when you need to. When studying/doing homework, take a 5-10 min. break every hour. Take a walk. Eat something.
When you're ready to throw your textbook against the wall, take a break. Then switch subjects - start working on your science (or whatever) homework instead.
The first few weeks of the new semester are hectic and overwhelming. It really will get better.

You'll get into a groove and settle down.
Classes and homework are my priority. Errands, appointments, etc. are next. Housework is last. That's just the way it is. I can catch up between semesters. (our college is on a traditional school schedule)
Talk to the other students in your classes! Its fun to get to meet new people, that you wouldn't normally have an opportunity to get to know. Also, they are full of extremely helpful information, like which math class has the most helpful prof, which classes are lighter homework, which classes are most interesting, etc. After a couple semesters, you'll also get to tell other students which classes and teachers are good.
Research your textbook prices. I've found that I can get my books a lot cheaper on-line than at the college bookstore. Resell them at the end of the semester.
And don't forget to fill out your FAFSA if you need financial aid.
Lastly, take a deep breath! If I can do this, you can, too.
Good luck!